2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid 1,3-Dihydro-3-oxo-1-isobenzofuranyl Ester
Talniflumate
CAS: 66898-62-2
Molecular Formula: C21H13F3N2O4
2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid 1,3-Dihydro-3-oxo-1-isobenzofuranyl Ester - Names and Identifiers
2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid 1,3-Dihydro-3-oxo-1-isobenzofuranyl Ester - Physico-chemical Properties
| Molecular Formula | C21H13F3N2O4 |
| Molar Mass | 414.33 |
| Density | 1.49±0.1 g/cm3(Predicted) |
| Melting Point | 165-167°C |
| Boling Point | 534.6±50.0 °C(Predicted) |
| Flash Point | 277.1°C |
| Solubility | Chlorform (Slightly), DMSO (Slightly), Methanol (Slightly) |
| Vapor Presure | 1.67E-11mmHg at 25°C |
| Appearance | Solid |
| Color | Off-White to Pale Yellow |
| Maximum wavelength(λmax) | ['287nm(CHCl3)(lit.)'] |
| Merck | 14,9044 |
| pKa | 2.72±0.10(Predicted) |
| Storage Condition | Store at +4°C |
| Stability | Acid Sensitive, Moisture Sensitive |
| Refractive Index | 1.625 |
| Physical and Chemical Properties | White to pale yellow crystalline powder. |
| Use | As a non-steroidal anti-inflammatory analgesic, it can be used for the adjuvant treatment of fibrous cyst and asthma |
2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid 1,3-Dihydro-3-oxo-1-isobenzofuranyl Ester - Risk and Safety
| RTECS | QT2999200 |
| Toxicity | LD50 orally in rats: 12000 mg/kg (Los) |
2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid 1,3-Dihydro-3-oxo-1-isobenzofuranyl Ester - Reference Information
| biological activity | Talniflumate (MSI-1995) is an anti-inflammatory agent in the treatment of cystic fibrosis, it is used as a mucin modulator in chronic obstructive pulmonary disease and asthma. Talniflumate is also a human Calcium-activated chloride channel. |
| Target | IC50: Ca 2 -activated Cl-channel (CaCC) |
| Animal Model: | CF mice with distal intestinal obstructive syndrome (DIOS) |
| Dosage: | 0.4 mg/g |
| Administration: | Oral chow; 21 days |
| Result: | Increased survival in a cystic fibrosis mouse model of distal intestinal obstructive syndrome. |
| Use | Tamoxifen is a non-steroidal anti-inflammatory and analgesic drug substance, and can be used for the adjuvant treatment of fibrous cysts and asthma. |
Last Update：2024-04-10 22:29:15
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View History
2-[[3-(Trifluoromethyl)phenyl]amino]-3-pyridinecarboxylic Acid 1,3-Dihydro-3-oxo-1-isobenzofuranyl Ester
Urea phosphate salt
Methyl 5-(aminosulphonyl)-2-methoxybenzoate
1H-Benzotriazole-1-acetamide, N-[1-(4-fluorophenyl)-2-oxo-2-[[(tetrahydro-2-furanyl)methyl]amino]ethyl]-N-(4-methoxyphenyl)-
120202-64-4
518305-38-9
3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
luoropropyl)-
N-(4-bromophenyl)-2-(3-cyano-2-methyl-1H-indol-1-yl)acetamide
WAY-357769
Urea phosphate salt
Methyl 5-(aminosulphonyl)-2-methoxybenzoate
1H-Benzotriazole-1-acetamide, N-[1-(4-fluorophenyl)-2-oxo-2-[[(tetrahydro-2-furanyl)methyl]amino]ethyl]-N-(4-methoxyphenyl)-
120202-64-4
518305-38-9
3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
luoropropyl)-
N-(4-bromophenyl)-2-(3-cyano-2-methyl-1H-indol-1-yl)acetamide
WAY-357769